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B12 is also contraindicated in Lebers disease , a hereditary optic nerve atrophic condition.

1 2 3 "Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation" (PDF)

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Semaglutide: Semaglutide is a GLP-1 receptor agonist that promotes weight loss primarily through appetite suppression and improved glycemic control, while AOD-9604 works directly on adipose tissue to enhance fat metabolism